李昕，药理学博士，主任药师、教授，党委委员、副院长，博士研究生/硕士研究生导师；

被授予长沙市卫生健康医学高层次人才、湖南省芙蓉计划卫生健康高层次人才-优秀学科带头人、中国药学会全国优秀药师、湖南省优秀药师、长沙市优秀医师、长沙市芙蓉标兵、长沙市名医等称号。

联系方式：xin-li@cssdsyy.com

抗感染药物临床药理学，新药临床研究与评价

1. 中国药理学会药物临床试验专业委员会委员会常务委员

2. 第一届湖南省药学会药物/器械临床试验与转化专业委员会副主任委员

1. 抗耐药微生物药物湖南省重点实验室，No.2023TP1013，主持

2. 湖南省自然科学基金，No.2020JJ9019，主持

3. 湖南省科技厅临床医疗技术创新引导项目，No.2021SK53001，主持

4. 湖南省自然科学基金面上项目，No.2023JJ30059，参与

5. 作为PI负责100余项企业委托课题

1. Rong Wang, Zhimei Huang, Zhenkun Wu, Xin Li*, Jian-Hui Jiang. Chemical Engineering of DNAzyme for Effective Biosensing and Gene Therapy. Small Methods. 2025 Feb 2:e2401514.

2. Rui Yang, Debiao Xiang, Fang Yuan, Yuan Yang, Pengkai Wang, Bing Xu , Xin Li*. Unraveling Neurotoxicity Discrepancies: Comparative In vitro and In vivo Analysis of Colistin and Polymyxin B and the Underlying Mechanisms. Mol Neurobiol. 2025 Apr;62(4):4562-4575.

3. Huan Tong, Yong Qiao, Yang Deng, Fang Yuan, Debiao Xiang, Siwei Guo, Bing Xu, Xin Li*."On-off" elution mechanism facilitates the rapid LC/MS/MS-based analysis of peptide antibiotics in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Feb 1;1252:124438.

4. Cong Cheng, Yuan Yuan, Fang Yuan, Xin Li. Acute kidney injury: exploring endoplasmic reticulum stress-mediated cell death. Front Pharmacol. 2024 Feb 12;15:1308733.

5. Debiao Xiang, Lili Zhou, Rui Yang, Fang Yuan, Yilin Xu , Yuan Yang, Yong Qiao, Xin Li. Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy. Int J Nanomedicine. 2024 Mar 5;19:2091-2112.

6. Miaomei Tian, Bingqian Yan, Rong Jiang, Candi Liu, You Li, Bing Xu, Siwei Guo, Xin Li. Activity of polymyxin B combined with cefepime-avibactam against the biofilms of polymyxin B-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae in in vitro and in vivo models. BMC Microbiol. 2024 Oct 16;24(1):409.

7. Liguang Xiong, Debiao Xiang, Fang Yuan, Huan Tong, Rui Yang, Lili Zhou, Bing Xu, Changhui Deng, Xin Li*. Piceatannol-3'-O-β-D-glucopyranoside attenuates colistin-induced neurotoxicity by suppressing oxidative stress via the NRF2/HO-1 pathway. Biomed Pharmacother. 2023 May;161:114419.

8. Gui-ying Xiao; Fang Yuan; Yang Deng; De-biao Xiang; Li-guang Xiong; Xin Li*; Yuan Li;Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway‐mediated antioxidant response, J Biochem Mol Toxicol,2023, 37(6): e23344.

9. Yang Deng; Jun-Yuan Gu; Xin Li*; Huan Tong; Si-Wei Guo; Bing Xu; You Li; Bi-Kui Zhang;Ying Li; Hai-Ying Huang; Gui-Ying Xiao ; Does Monitoring Total and Free Polymyxin B1 Plasma Concentrations Predict Polymyxin B-Induced Nephrotoxicity? A Retrospective Study in Critically Ill Patients, Infectious Diseases and Therapy, 2022, 11(4): 1591-1608.

10. Yang Deng; Xi-lin Luo; Xin Li; Yi-sha Xiao; Bing Xu; Huan Tong ; Screening of Biomarkers and Toxicity Mechanisms of Rifampicin-Induced Liver Injury Based on Targeted Bile Acid Metabolomics, Frontiers in Pharmacology, 2022 Jun 10;13:925509.

11. Siwei Guo, Xin Li*, You Li, Huan Tong, Minji Wei, Bingqian Yan, Miaomei Tian, Bing Xu, Jing Shao. Sitafloxacin pharmacokinetics/pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model. J Antimicrob Chemother. 2022 Dec 23;78(1):141-149.

12. Junchen Huang, Siwei Guo, Xin Li*, Fang Yuan, You Li, Bing Xu, Junyuan Gu, Yong Qiao. Nemonoxacin Enhances Antibacterial Activity and Anti-Resistance Mutation Ability of Vancomycin against Methicillin-Resistant Staphylococcus aureus in an In Vitro Dynamic Pharmacokinetic/Pharmacodynamic Model. Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0180021. doi: 10.1128/AAC.01800-21. Epub 2021 Dec 13. PMID: 34902266; PMCID: PMC8846321.

13. Bing Xu, Yang Deng, Xin Li*, Siwei Guo, Zhenyue Gao, Wenyuan Xu, Yuan Li, Ping Zhang, Lingling Zhang, Junchen Huang. Development and validation of a LC-MS/MS method for simultaneous determination of TQ-A3326 and its major metabolites in human plasma, urine and feces: application to pharmacokinetic assay. Xenobiotica. 2020 Dec;50(12):1451-1460.

14. 一种吸入式制剂防污染负压给药室，国家发明专利，专利号：ZL201910560409.1，排名第1

15. 一种可变温的冰水浴盒，实用新型专利，专利号：ZL201920695671.2，排名第1

16. 一种药敏试验卡干燥方法，国家发明专利，专利号：ZL201810470281.5，排名第2

17. 用于生物等效性研究的鼻喷剂自动给药装置，实用新型专利，专利号：201922258145.2，排名第1

18. 用于生物等效性研究的鼻喷剂自动给药装置及其使用方法，国家发明专利，专利号：ZL 201911297178.6，排名第1

19. 一种适用于培养生物被膜细菌的装置，实用新型专利，专利号：ZL 202420606220.8，排名第1

20. 科研菌种数据库系统V2.0，软件著作权，登记号：2023SR0977991